Rob Noble

Rob Noble

Post Doc withMichael Hochberg

robjohnnoble (at) gmail (point) com
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Blog: These few lines

Research interests:

I use mathematical and computational models to investigate evolutionary and ecological systems. I am currently working, in close collaboration with laboratory scientists, on models of cancer risk, tumour evolution, and new ways to prevent drug resistance. My methods include agent-based models, game theory, analysis of dynamical systems, demographic models, and Bayesian data analysis.

Previous research

During my PhD at the University of Oxford (2009-2013) I used mathematical models, informed by statistical analysis of laboratory data, to understand the immune evasion mechanisms of the malaria parasitePlasmodium falciparum.

Publications and preprints (as of January 2017)

  • Hochberg ME, Noble R (2017). A framework for how environment contributes to cancer risk.Ecology Letters. 20(2) 117-134; doi:10.1111/ele.12726.
  • Vasse M*, Noble R*, Akhmetzhanov AR, Torres-Barceló C, Gurney J, Simon Benateau, Gougat-Barbera C, Kaltz O, Hochberg ME (2017). Antibiotic stress selects against cooperation in the pathogenic bacteriumPseudomonas aeruginosa.Proc. Natl. Acad. Sci. USA.114 (3) 546-551; doi:10.1073/pnas.1612522114. [* equal contributions]
  • Hochberg ME, Noble R, Braude S (2016). A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats.biorXiv.doi:10.1101/079012.
  • Noble R, Kaltz O, Nunney L, Hochberg ME (2016). Overestimating the role of environment in cancers.Cancer Prev. Res.doi:10.1158/1940-6207.CAPR-16-0126.
  • Noble R, Kaltz O, Hochberg ME (2015). Peto’s paradox and human cancers.Phil. Trans. R. Soc. B. 2015 370 20150104. doi:10.1098/rstb.2015.0104.
  • Noble R*, Christodoulou Z*, Pinches R, Kyes S, Recker M, Newbold CI (2013). The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria.eLife. 2013 Sep 17;2:e01074. doi:10.7554/eLife.01074. [* equal contributions]
  • Noble R, Recker M (2012) A statistically rigorous method for determining antigenic switching networks.PLoS ONE7(6). doi: 10.1371/journal.pone.0039335.
  • Fastman Y, Noble R, Recker M, Dzikowski R (2012). Erasing the Epigenetic Memory and Beginning to Switch—The Onset of Antigenic Switching of var Genes in Plasmodium falciparum.PLoS ONE7(3). doi: 10.1371/journal.pone.0034168.