Rob Noble

Post Doc withMichael Hochberg

robjohnnoble (at) gmail (point) com
@robjohnnoble
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Blog: These few lines

Research interests:

I use mathematical and computational models to investigate evolutionary and ecological systems. I am currently working, in close collaboration with laboratory scientists, on models of cancer risk, tumour evolution, and new ways to prevent drug resistance. My methods include agent-based models, game theory, analysis of dynamical systems, demographic models, and Bayesian data analysis.

Previous research

During my PhD at the University of Oxford (2009-2013) I used mathematical models, informed by statistical analysis of laboratory data, to understand the immune evasion mechanisms of the malaria parasitePlasmodium falciparum.

Publications and preprints (as of January 2017)

Hochberg ME, Noble R (2017). A framework for how environment contributes to cancer risk.Ecology Letters. 20(2) 117-134; doi:10.1111/ele.12726.
Vasse M*, Noble R*, Akhmetzhanov AR, Torres-Barceló C, Gurney J, Simon Benateau, Gougat-Barbera C, Kaltz O, Hochberg ME (2017). Antibiotic stress selects against cooperation in the pathogenic bacteriumPseudomonas aeruginosa.Proc. Natl. Acad. Sci. USA.114 (3) 546-551; doi:10.1073/pnas.1612522114. [* equal contributions]
Hochberg ME, Noble R, Braude S (2016). A Hypothesis to Explain Cancers in Confined Colonies of Naked Mole Rats.biorXiv.doi:10.1101/079012.
Noble R, Kaltz O, Nunney L, Hochberg ME (2016). Overestimating the role of environment in cancers.Cancer Prev. Res.doi:10.1158/1940-6207.CAPR-16-0126.
Noble R, Kaltz O, Hochberg ME (2015). Peto’s paradox and human cancers.Phil. Trans. R. Soc. B. 2015 370 20150104. doi:10.1098/rstb.2015.0104.
Noble R*, Christodoulou Z*, Pinches R, Kyes S, Recker M, Newbold CI (2013). The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria.eLife. 2013 Sep 17;2:e01074. doi:10.7554/eLife.01074. [* equal contributions]
Noble R, Recker M (2012) A statistically rigorous method for determining antigenic switching networks.PLoS ONE7(6). doi: 10.1371/journal.pone.0039335.
Fastman Y, Noble R, Recker M, Dzikowski R (2012). Erasing the Epigenetic Memory and Beginning to Switch—The Onset of Antigenic Switching of var Genes in Plasmodium falciparum.PLoS ONE7(3). doi: 10.1371/journal.pone.0034168.